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Cilostazol for Secondary Prevention of Stroke: Should the Guidelines Perhaps Be Extended?

George Galyfos1, Argyri Sianou2

  • 1Division of Vascular Surgery, Department of Propaedeutic Surgery, University of Athens Medical School, Hippocration Hospital, Athens, Greece.

Vascular Specialist International
|September 29, 2017
PubMed

Insights

Cilostazol effectively treats intermittent claudication in peripheral artery disease. Further research is needed to determine its role in preventing cerebrovascular events, despite existing clinical data.

Area of Science:

  • Pharmacology and Cardiovascular Medicine

Background:

  • Cilostazol is a novel antiplatelet agent.
  • It is a recommended first-line treatment for intermittent claudication.
  • Its role in cerebrovascular events is not yet established.

Purpose of the Study:

  • To review the mechanisms of action of cilostazol.
  • To present recent clinical data on cilostazol's efficacy.
  • To assess the potential for extending clinical guidelines for cilostazol.

Main Methods:

  • Systematic review of randomized and pooled clinical data.
  • Analysis of pharmacological mechanisms.

Main Results:

  • Sufficient data support cilostazol for peripheral artery disease.
  • Extensive clinical data exist for cerebrovascular events, but guidelines are not yet extended.
  • Cilostazol exhibits antiplatelet and vasodilatory properties.

Conclusions:

  • Cilostazol is a proven treatment for intermittent claudication.
  • Further evaluation of existing data is necessary to determine its use in cerebrovascular disease prevention.
  • Official guidelines may need to be updated based on comprehensive data analysis.

Keywords:
GuidelineSecondary preventionStroke

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