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Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI
Masayuki Munekane1,2, Shinji Motomura3, Shinichiro Kamino1,3
1Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Biochemistry and Biophysics Reports
|September 29, 2017
Summary
This study introduces Gamma-ray Emission Imaging (GREI) to track antidiabetic zinc (Zn) complexes in vivo. The imaging revealed that Zn accumulation in the heart correlates with the potent antidiabetic activity of the [Zn(opt)2] complex.
Area of Science:
- Biomedical imaging
- Nuclear medicine
- Pharmacology
Background:
- Zinc complexes show promise as antidiabetic agents, but their pharmacological mechanisms remain unclear due to a lack of biodistribution studies.
- Noninvasive imaging techniques are crucial for understanding drug candidate distribution in living organisms.
Purpose of the Study:
- To apply Gamma-ray Emission Imaging (GREI) for noninvasive biodistribution analysis of antidiabetic zinc complexes.
- To investigate the relationship between zinc complex distribution and antidiabetic activity.
Main Methods:
- Produced 65Zn via the natCu(p,n) reaction for GREI experiments.
- Administered 65Zn-labeled di(1-oxy-2-pyridinethiolato)zinc [Zn(opt)2], ZnCl2, and di(l-histidinato)zinc intravenously.
- Visualized biodistribution using GREI and validated with invasive assays.
Main Results:
- GREI successfully visualized the biodistribution of 65Zn-labeled zinc complexes in vivo.
- Accumulation of 65Zn was observed in the cardiac blood pool for the potent antidiabetic agent [Zn(opt)2].
- GREI proved effective for biodistribution analysis of antidiabetic zinc complexes.
Conclusions:
- GREI is a powerful tool for studying the biodistribution of antidiabetic zinc complexes.
- Slow zinc elimination from the blood may be linked to the antidiabetic efficacy of [Zn(opt)2].
- This study provides new insights into the pharmacokinetics of antidiabetic zinc complexes.
