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Updated: Feb 22, 2026

Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance
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Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin

Abigail H Davies1, Joanna McGlashan2, Mareike G Posner1

  • 1Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

Biochemistry and Biophysics Reports
|September 29, 2017
PubMed

Keywords:
ADP-ribosylationARTT, ADP-ribosyl turn-turnC2, C. botulinum toxin C2.CDT, C. difficile binary toxinCDTa, C. difficile toxin domain aCDTb, C. difficile toxin domain b residues 1-876CDTb′, residues 42-876 of CDTb (no signal peptide sequence)CDTb′′, residues 209-876 of CDTb (no activation domain)Clostridium difficile binary toxinEnzymologyIa, C. perfringens Iota binary toxinMutagenesisTcdA, C. difficile exotoxin ATcdB, C. difficile exotoxin BrCDTa, recombinant wild-type C. difficile toxin domain a

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