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Alpha-adrenoceptor-blocking properties of some trypanocidal diamidines
U Steinmann1, C J Estler, O Dann
1Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, F.R.G.
Archives Internationales De Pharmacodynamie Et De Therapie
|December 1, 1987
Abstract:
A series of trypanocidal diamidines and diimidazolines known to cause severe hypotension were tested for their alpha-adrenoceptor blocking properties in vitro. At the postsynaptic alpha 1-receptor of the guinea-pig aorta in vitro all compounds at doses of 0.5 to 50 mumol/l showed weak antagonistic effects against noradrenaline. Similar results were obtained at the presynaptic alpha 2-receptor of the rat vas deferens.