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Updated: Feb 22, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
[Wastewater treatment based on biofilm regulation by Lux type quorum sensing system-a review]
Chang Zhao1, Ning Wang1, Wenzhao Wang1,2
1School of Environment and Energy, Shenzhen Graduate School, Peking University, Shenzhen 518055, Guangdong, China.
Abstract:
Studies on biofilm regulation based on Lux type quorum sensing system in wastewater treatment have attracted much attention. The intervention of quorum sensing system includes both mechanisms of positive and negative control. The positive invigorating effect improves the efficiency of biofilm wastewater treatment, promotes the production of extracellular polymeric substance (EPS) and soluble microbial products (SMP), and increases the yield of biofilm. The negative weakening effect of quorum sensing can decompose the signal molecules needed in the process of biofilm formation, interrupts the gene expression process of biofilm formation, and inhibits the formation of biofilm on MBR membrane surface effectively. The further study of the structure and mechanism of N-acyl homoserine lactone (AHLs), the immobilization technology and application of quorum quenching bacteria, the synergistic effect verification of different biofouling control methods and the application feasibility of quorum sensing system based technology in more wastewater treatment fields are the next important researches to explore.
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