Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

13.0K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
13.0K
Tonsillitis II: Management01:26

Tonsillitis II: Management

467
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
467
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

6.9K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
6.9K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

2.0K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
2.0K
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

2.4K
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
2.4K
The Physiology of Taste01:24

The Physiology of Taste

8.0K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term add-on fibrate therapy in Primary Sclerosing Cholangitis: Safety, biochemical response, and disease progression.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same author

Intrapartum sonographic evaluation of fetal head descent in relation to maternal position: comparison between dorsal lithotomy and kneeling squat positions.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

Indication for biologics in a real-world cohort of dupilumab treated chronic rhinosinusitis with nasal polyps patients according to international recommendations: evidence from the European CRS Outcome Registry (CHRINOSOR).

Rhinology·2025
Same author

Efficacy and tolerability of house dust mites subcutaneous immunotherapy with monomeric allergoid: an Italian multicenter study.

European annals of allergy and clinical immunology·2024
Same author

Peripheral blood BDNF and soluble CAM proteins as possible markers of prolonged disorders of consciousness: a pilot study.

Scientific reports·2024
Same author

Correlation between bituberous diameter and mode of delivery in a cohort of low-risk nulliparous women.

European journal of obstetrics, gynecology, and reproductive biology·2023
Same journal

Identification of circRNA-mediated competing endogenous RNA network in the development of bladder urothelial carcinoma.

Journal of biological regulators and homeostatic agents·2021
Same journal

Dimethyl fumarate attenuates lipopolysaccharide-induced acute lung injury by inhibiting inflammation and oxidative stress.

Journal of biological regulators and homeostatic agents·2021
Same journal

Expression of NLR and IL-1β and their predictive efficacy value in acute myocardial infarction patients treated with aspirin combined with clopidogrel.

Journal of biological regulators and homeostatic agents·2021
Same journal

CircRNA (circ_0008057) promotes uremic serum-mediated proliferation and migration of vascular smooth muscle cells via miR-370/PLk1 signaling pathway.

Journal of biological regulators and homeostatic agents·2021
Same journal

Overexpression of miR-150-5p alleviates lipopolysaccharide-induced A549 cell injury in type II alveolar epithelial cells by inhibiting the FSTL1 signaling pathway.

Journal of biological regulators and homeostatic agents·2021
Same journal

Efficacy of early oral and perioral physiotherapy on feeding autonomy in preterm infants: results of randomized controlled trials.

Journal of biological regulators and homeostatic agents·2021
See all related articles

Related Experiment Video

Updated: Feb 22, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.7K

Is lingual tonsil a preferential target for processing sublingually administered materials?

S Masieri1, C Incorvaia2, C Cavaliere1

  • 1Department of Otorhinolaryngology, Sapienza University, Rome, Italy

Journal of Biological Regulators and Homeostatic Agents
|September 29, 2017
PubMed
Summary
This summary is machine-generated.

The lingual tonsil, part of Waldeyer's ring, may act as a key immune site in the mouth. Research suggests it processes antigens to activate T and B lymphocytes, potentially aiding medical treatments.

More Related Videos

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
08:09

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Published on: November 16, 2015

16.5K
CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

26.4K

Related Experiment Videos

Last Updated: Feb 22, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.7K
Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
08:09

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Published on: November 16, 2015

16.5K
CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

26.4K

Area of Science:

  • Immunology
  • Oral Biology
  • Otorhinolaryngology

Background:

  • The oral cavity plays a crucial role in immune responses, distinguishing between harmless and harmful antigens.
  • Waldeyer's ring, comprising tonsillar tissues, is central to immune tolerance and reactivity.
  • These tissues modulate both innate and adaptive immunity, involving toll-like receptors.

Purpose of the Study:

  • To investigate the immunological function of the lingual tonsil.
  • To explore the lingual tonsil's role as an antigen-sampling site in the oral cavity.
  • To assess the potential of lingual tonsil immune activity for medical applications.

Main Methods:

  • Review of existing animal and human studies on oral immunology.
  • Analysis of antigen trafficking to the lingual tonsil.
  • Evaluation of T and B lymphocyte activation pathways.

Main Results:

  • Animal studies indicate the lingual tonsil samples and processes antigens to stimulate lymphocytes.
  • Recent human studies show rapid antigen transport to the lingual tonsil from under the tongue.
  • These findings suggest a significant inductive role for the lingual tonsil in immune responses.

Conclusions:

  • The lingual tonsil is likely an important inductive site for immune responses in the human oral cavity.
  • Its role in antigen processing and lymphocyte activation warrants further in-depth investigation.
  • Understanding this function could lead to novel medical treatment strategies.