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cDNA cloning of esterase 1, the major esterase activity in mouse plasma
T L Genetta1, P D'Eustachio, S S Kadner
1Department of Environmental Medicine, New York University Medical Center, New York 10016.
Biochemical and Biophysical Research Communications
|March 30, 1988
Abstract:
We report here the cloning of a partial cDNA for Esterase 1, the major esterase activity in mouse plasma. A 470 base pair insert was isolated from a lambda gt11 cDNA library constructed from mouse liver poly A+ RNA, and identified by hybrid selected translation. We show that the sexual dimorphism displayed in the plasma levels of this protein is caused by a difference at the level of transcription. In addition, RFLP data using mouse recombinant inbred strains mapped this clone at the Es-1 locus on mouse chromosome 8.