Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The decrease of low serum gamma glutamyl transferase during short-term abstinence.

J Weill1, F Schellenberg, A M Le Goff

  • 1Laboratoire de Biochimie, Centre Hospitalier Universitaire Trousseau, Tours, France.

Alcohol (Fayetteville, N.Y.)
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations on the measurement and use of the alcohol consumption biomarker CDT. A position paper from the IFCC Working Group on CDT standardisation.

Clinica chimica acta; international journal of clinical chemistry·2024
Same author

Marker of coxsackievirus-B4 infection in saliva of patients with type 1 diabetes.

Diabetes/metabolism research and reviews·2017
Same author

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population.

International journal of obesity (2005)·2012
Same author

[Autoimmune polyendocrine syndrome type 1].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2010
Same author

Childhood-onset narcolepsy, obesity and puberty in four consecutive children: a close temporal link.

Journal of pediatric endocrinology & metabolism : JPEM·2010
Same author

Autoimmune polyendocrine syndrome type 1 in north-western France: AIRE gene mutation specificities and severe forms needing immunosuppressive therapies.

Hormone research in paediatrics·2010
Same journal

Regulation of amygdala and dopamine system in naïve and chronic alcohol states.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

The Effects of Developmental Ethanol Exposure & Postnatal Choline Supplementation on Long-Term Choline Metabolism.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Early ethanol exposure during gestation and lactation disrupts gut integrity and enhances ethanol intake in C57BL/6 mice offspring.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Effects of acute alcohol on pain-related activity of the anterior and posterior insular cortices.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Adolescent ethanol exposure produces sex-dependent modulation of ethanol-induced analgesia and cell type-specific vlPAG activation.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure.

Alcohol (Fayetteville, N.Y.)·2026
See all related articles

The serum gamma glutamyl transferase (GGT) decrease test effectively identifies alcohol abuse. This test shows high sensitivity (0.90) even when initial GGT levels are within the normal range.

Area of Science:

  • Clinical Biochemistry
  • Addiction Medicine

Background:

  • Elevated serum gamma glutamyl transferase (GGT) is a common indicator of alcohol abuse.
  • The diagnostic utility of GGT decrease following alcohol withdrawal in patients with normal baseline levels is less understood.

Purpose of the Study:

  • To evaluate the sensitivity of the GGT decrease test for detecting alcohol abuse in patients, including those with normal initial GGT levels.
  • To assess the efficacy of a short period of alcohol abstinence in revealing alcohol consumption through GGT changes.

Main Methods:

  • A study involving 107 inpatients at a detoxification center.
  • Monitoring of serum GGT levels before and after a period of alcohol withdrawal (approximately seven days).
  • Analysis of GGT level changes in relation to initial GGT values (elevated or within reference range).

Related Experiment Videos

Main Results:

  • 81% of patients presented with elevated serum GGT upon admission.
  • Serum GGT decreased significantly in all but one patient with initially high GGT after alcohol withdrawal.
  • A significant decrease in GGT was observed in 50% of patients with initially normal GGT levels.
  • Overall, a decrease in GGT was observed in 96 out of 107 patients, yielding a sensitivity of 0.90 for the decrease test.

Conclusions:

  • The GGT decrease test demonstrates high sensitivity (0.90) for detecting alcohol abuse.
  • This diagnostic approach is effective even when initial serum GGT levels are within the normal reference range.
  • The findings support the broader application of the GGT decrease test in evaluating potential alcohol abuse.