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Polyclonal lymphocytosis of T-cells associated with human T-cell leukemia virus I
D N Posnett1, H A McGrath, R A Scott
1Department of Medicine, Cornell University Medical College, New York, New York 10021.
Cancer Research
|May 1, 1988
Abstract:
A patient with antibodies to human T-cell leukemia virus type I and the presence of integrated sequences of this virus in T-lymphocytes was investigated. In contrast to previous reports, the T-cell lymphocytosis was found to be polyclonal by analysis of human T-cell leukemia virus type I integration sites and T-cell antigen receptor rearrangements. Polyclonal T-cell infection by human T-cell leukemia virus type I may represent an infrequently observed stage of leukemogenesis.