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Related Experiment Video

Updated: Feb 22, 2026

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

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A Molecular Code for Imprinting Drug-Cue Associations.

Adrian M Gomez¹, Michael R Bruchas²

¹Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

|September 29, 2017

Summary

Nuclear histone deacetylase HDAC5 targets regulate drug-induced behaviors. This study shows HDAC5 nuclear targets mediate cocaine-associated stimulus effects, impacting neuroadaptations.

Keywords:

HDAC5 Npas4 cocaine nucleus accumbens

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Area of Science:

Neuroscience
Molecular Biology
Pharmacology

Background:

Histone deacetylase 5 (HDAC5) plays a role in drug-induced behavioral neuroadaptations.
The precise mechanisms by which HDAC5 influences these behaviors are not fully understood.

Purpose of the Study:

To investigate the role of nuclear HDAC5 targets in mediating the behavioral effects of rewarding drugs.
To explore the regulation of cocaine-associated stimuli by HDAC5.

Main Methods:

The study by Taniguchi et al. (2017) likely involved molecular and behavioral analyses in preclinical models.
Investigated the impact of HDAC5 activity and its targets on responses to cocaine.

Main Results:

Nuclear HDAC5 targets were identified as key mediators of drug-induced behavioral effects.
HDAC5 activity regulates the behavioral impact of cocaine-associated stimuli.

Conclusions:

Nuclear HDAC5 and its targets are crucial for understanding drug addiction mechanisms.
Targeting HDAC5 pathways may offer novel therapeutic strategies for substance use disorders.