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Troponin I Levels in Asymptomatic Hemodialysis Patients

Diego Castini1, Simone Persampieri, Riccardo Floreani

  • 1Division of Cardiology, San Paolo Hospital, University of Milan, Italy.

Blood Purification
|September 29, 2017
PubMed

Insights

Hemodialysis (HD) does not significantly alter cardiac troponin I (cTnI) levels in end-stage renal disease (ESRD) patients. Observed changes in cTnI during HD are clinically insignificant, preserving the diagnostic accuracy of cTnI assays in ESRD.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Chemistry

Background:

  • Elevated cardiac troponin I (cTnI) is common in end-stage renal disease (ESRD) without apparent cardiac disease.
  • The impact of hemodialysis (HD) on cTnI levels in ESRD patients remains unclear.

Purpose of the Study:

  • To investigate the effect of hemodialysis (HD) on cardiac troponin I (cTnI) levels in patients with end-stage renal disease (ESRD).

Main Methods:

  • 30 asymptomatic ESRD patients undergoing maintenance HD were studied.
  • cTnI levels were measured before (pre-HD) and after (post-HD) dialysis sessions.
  • Comparisons were made between weekly HD sessions and pre- vs. post-HD levels.

Main Results:

  • Baseline median cTnI was 0.018 ng/mL, with 30% of patients showing elevated levels (>0.034 ng/mL).
  • A statistically significant decrease in pre-HD cTnI was observed between the first and second weekly sessions (p=0.002).
  • No significant differences were found between pre-HD and post-HD cTnI levels, or between subsequent weekly sessions.

Conclusions:

  • Hemodialysis (HD) does not significantly impact cardiac troponin I (cTnI) levels in ESRD patients.
  • Observed changes in cTnI during HD are clinically irrelevant.
  • HD does not compromise the diagnostic utility of cTnI assays in ESRD patients.
Abstract

Keywords:
End-stage renal diseaseHemodialysisTroponin I

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