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Altered Expression Pattern of CD55 and CD59 on Red Blood Cells in Anemia of Chronic Kidney Disease

Lama Al-Faris, Salah Al-Humood, Fatma Behbehani

    Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
    |September 29, 2017
    PubMed

    Insights

    Red blood cell CD55 and CD59 expression is altered in anemic chronic kidney disease (CKD) patients. This altered expression may contribute to the development of anemia in CKD patients.

    Area of Science:

    • Hematology
    • Nephrology
    • Immunology

    Background:

    • Anemia is a common complication of chronic kidney disease (CKD).
    • The role of complement regulatory proteins on red blood cells (RBCs) in CKD-related anemia is not fully understood.
    • CD55 and CD59 are key regulators of complement activation on cell surfaces.

    Purpose of the Study:

    • To investigate the expression patterns of CD55 and CD59 on RBCs in anemic CKD patients.
    • To identify factors influencing CD55 and CD59 expression in this population.

    Main Methods:

    • Flow cytometry was used to analyze CD55 and CD59 expression on RBCs.
    • Ninety-one anemic CKD patients and 80 healthy controls were studied.
    • CKD patients were stratified into subgroups based on therapy.

    Main Results:

    • Anemic CKD patients exhibited significantly higher proportions of CD55- and CD59-deficient RBCs compared to healthy controls.
    • Mean fluorescence intensity of CD55 and CD59 was lower in CKD patients.
    • Hemoglobin levels were inversely correlated with deficient RBC proportions, and expression varied across CKD subgroups.

    Conclusions:

    • Altered expression of CD55 and CD59 on RBCs is a characteristic finding in anemic CKD patients.
    • These alterations may play a role in the pathogenesis of anemia associated with CKD.
    • Therapeutic interventions and disease severity may influence complement regulatory protein expression on RBCs in CKD.
    Abstract

    Keywords:
    AnemiaCD55CD59Chronic kidney disease

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