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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Masked Hypertension is Associated With Cognitive Decline in Geriatric Age-Geriatric MASked Hypertension and Cognition
Mert Esme1, Burcu Balam Yavuz2, Bunyamin Yavuz3
1Faculty of Medicine, Department of Internal Medicine, Hacettepe University, Ankara, Turkey.
Insights
Masked hypertension, a condition with normal office blood pressure but high ambulatory readings, is linked to decreased cognitive function in geriatric patients. Early detection and cognitive assessment are crucial for managing this condition.
Area of Science:
- Geriatric Medicine
- Cardiology
- Neurology
Background:
- Masked hypertension is defined by normal office blood pressure but elevated ambulatory blood pressure measurements.
- The impact of masked hypertension on cognitive functions remains largely unexamined.
- Hypertension is a known risk factor for cognitive decline.
Purpose of the Study:
- To investigate the association between masked hypertension and cognitive function in geriatric patients.
- To determine if masked hypertension affects cognitive performance in older adults.
Main Methods:
- 102 normotensive geriatric outpatients were assessed using ambulatory blood pressure monitoring (ABPM).
- Patients underwent comprehensive geriatric and neuropsychological assessments.
- Masked hypertension diagnosis followed the 2013 European Society of Cardiology guidelines.
Main Results:
- 43% of participants were diagnosed with masked hypertension.
- Patients with masked hypertension showed significantly lower scores on the Mini-Mental State Examination (MMSE), Quick Mild Cognitive Impairment Test (QMCI), and Categorical Fluency Test.
- A non-significant trend towards lower scores on the Montreal Cognitive Assessment Scale was observed in the masked hypertension group.
Conclusions:
- Geriatric patients with masked hypertension may experience diminished cognitive functions compared to normotensive individuals.
- Masked hypertension should be considered in the assessment of older adults.
- Cognitive assessment is recommended upon detection of masked hypertension to identify early cognitive dysfunction.
Background:
Masked hypertension is described as high ambulatory blood pressure measurements (ABPM) where office blood pressure measurements are normal. Effect of hypertension on cognitive functions is well known. However, the effect of masked hypertension on cognitive functions is unclear. The aim of this study is to examine the relationship between masked hypertension and cognitive functions.
Methods:
One hundred-two normotensive patients admitted to the Geriatric Medicine outpatient clinic were included. Exclusion criteria were hypertension, dementia, major depression, and usage of antihypertensive medication. All patients underwent ABPM procedures and average daytime blood pressure, mean blood pressure at night and the 24-hour average blood pressure measurements were recorded. Comprehensive geriatric assessment tests and neuropsychological tests were administered. The diagnosis of masked hypertension was based on the definitions in the 2013 guideline of the European Society of Cardiology.
Results:
Forty-four patients (43%) were diagnosed with masked hypertension. Patients with masked hypertension had significantly lower scores on Mini-Mental State Examination (MMSE) test, Quick Mild Cognitive Impairment Test (QMCI), and Categorical Fluency Test than the normotensive patients (p = .011; p = .046; and p = .004; respectively). Montreal Cognitive Assessment Scale test score was lower in masked hypertension, although this was not statistically significant.
Conclusion:
This study may indicate that geriatric patients with masked hypertension, compared to normotensive patients have decreased cognitive functions. Masked hypertension should be kept in mind while assessing older adults. When masked hypertension is detected, cognitive assessment is essential to diagnose possible cognitive dysfunction at early stage.
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