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Related Concept Videos

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Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
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Related Experiment Video

Updated: Feb 22, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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All Paths Lead to TRIM25.

Hengbo Zhou1, James C Costello2

  • 1Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Trends in Cancer
|September 30, 2017
PubMed
Summary
This summary is machine-generated.

Researchers identified tripartite motif containing 25 (TRIM25) as a key regulator of breast cancer metastasis. Targeting TRIM25 may offer a therapeutic strategy to control the spread of cancer by modulating metastatic gene expression.

Keywords:
TRIM25breast cancermetastasisnetwork inferencetranscription

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Area of Science:

  • Oncology
  • Molecular Biology
  • Systems Biology

Background:

  • Metastasis is a complex process driven by specific gene expression changes.
  • Identifying key regulators of metastatic gene signatures is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To identify key factors regulating the transition from primary to metastatic breast cancer.
  • To investigate the role of tripartite motif containing 25 (TRIM25) in controlling metastatic gene signatures.

Main Methods:

  • A systems biology approach was employed, integrating computational, in vitro, and in vivo experiments.
  • Analysis focused on identifying regulators of transcriptional and post-transcriptional metastatic gene signatures.

Main Results:

  • Tripartite motif containing 25 (TRIM25) was identified as a key regulator of metastatic gene signatures in breast cancer.
  • TRIM25 influences metastatic progression at both transcriptional and post-transcriptional levels.

Conclusions:

  • TRIM25 plays a critical role in governing metastatic gene expression programs in breast cancer.
  • Targeting TRIM25 presents a promising therapeutic avenue for controlling cancer metastasis due to its broad regulatory role.