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JARID1 Histone Demethylases: Emerging Targets in Cancer

Kayla M Harmeyer1, Nicole D Facompre1, Meenhard Herlyn2

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

Trends in Cancer
|September 30, 2017
PubMed

Insights

JARID1 proteins are histone demethylases involved in cell development and cancer. Understanding their varied roles is key to developing targeted JARID1 inhibitors for cancer therapy.

Area of Science:

  • Biochemistry and Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • JARID1 proteins are H3K4 histone demethylases regulating cell fate and epigenetic plasticity.
  • They participate in repressive transcriptional complexes and affect chromatin structure.
  • Their functions in normal development and cancer are context-dependent and include oncogenic and tumor-suppressive roles.

Purpose of the Study:

  • To review the diverse and context-specific functions of JARID1 proteins.
  • To discuss their roles in normal cell fates and malignant transformation.
  • To explore the implications for developing JARID1 inhibitors in cancer therapy.

Main Methods:

  • Literature review of JARID1 protein functions.
  • Analysis of JARID1 roles in cell development and cancer.
  • Synthesis of information on JARID1 protein isoforms and their impact.

Main Results:

  • JARID1 proteins exhibit context-dependent oncogenic and tumor-suppressive functions.
  • They contribute to stem cell-like dedifferentiation, tumor aggressiveness, and therapy resistance.
  • The understanding of their broader chromatin regulatory effects is still evolving.

Conclusions:

  • JARID1 proteins are critical epigenetic regulators with dual roles in cancer.
  • Targeted inhibition of JARID1 proteins holds promise for cancer therapy.
  • Further research into context-specific functions is needed to optimize inhibitor utilization.
Keywords:
JARID1AJARID1BJARID1CJARID1DKDM5cancer epigenetics

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