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Onchocerca volvulus: The Road from Basic Biology to a Vaccine.
Sara Lustigman1, Benjamin L Makepeace2, Thomas R Klei3
1Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY, USA.
Trends in Parasitology
|September 30, 2017
Summary
New vaccines are urgently needed to combat river blindness (onchocerciasis) due to ivermectin resistance. This review details progress in developing onchocerciasis vaccines for clinical use.
Area of Science:
- Neglected tropical diseases
- Parasitic diseases
- Vaccinology
Background:
- Human onchocerciasis, or river blindness, causes significant disability in sub-Saharan Africa.
- Mass drug administration with ivermectin is the primary elimination strategy but faces challenges.
- Emerging drug resistance in parasites necessitates novel intervention tools.
Purpose of the Study:
- To review the progress of onchocerciasis vaccine development.
- To highlight advancements from research toward clinical application.
Main Methods:
- Literature review of onchocerciasis vaccine research.
- Analysis of progress in preclinical and clinical development stages.
Main Results:
- Significant research efforts are underway to develop onchocerciasis vaccines.
- Progress has been made in advancing vaccine candidates from laboratory research.
Conclusions:
- Preventive and therapeutic vaccines are crucial new tools for onchocerciasis elimination.
- Continued research and development are vital to bring effective vaccines to the clinic.
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