Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diversity and assembly mechanisms of Porphyromonas gingivalis fimbriae: Conservation and structural heterogeneity of type V fimbriae.

Journal of oral biosciences·2026

Same author

Identification of a LolB-like protein in Porphyromonas gingivalis reveals selective LolA-LolB pairing.

Scientific reports·2026

Same author

Autoantibodies to Joint-Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Same author

Multi-omics analysis of associations between host demographics and saliva metabolome, sugar profiles, and microbiome profiles.

Scientific reports·2026

Same author

Correction: Razooqi et al. <i>Aggregatibacter actinomycetemcomitans</i> and <i>Filifactor alocis</i> as Associated with Periodontal Attachment Loss in a Cohort of Ghanaian Adolescents. <i>Microorganisms</i> 2022, <i>10</i>, 2511.

Microorganisms·2026

Same author

Oral microbiota in an aging Swedish population with high dental disease burden: an observational registry-based study.

Frontiers in oral health·2026

Search research articles

Related Experiment Video

Updated: Feb 22, 2026

Purification of a High Molecular Mass Protein in Streptococcus mutans

Purification of a High Molecular Mass Protein in Streptococcus mutans

Published on: September 14, 2019

Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development.

Anders Esberg¹, Nongfei Sheng¹, Lena Mårell¹

¹Department of Odontology/cariology, Umeå University, SE-901 87 Umeå, Sweden.

|September 30, 2017

Summary

Specific Streptococcus mutans adhesin types predict individual dental caries development. Identifying these subtypes in saliva can guide personalized oral care strategies for better prevention.

Keywords:

Adhesion Chronic infections Dental caries SpaP Streptococcus mutans Virulence

More Related Videos

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Concurrent Quantification of Cellular and Extracellular Components of Biofilms

Concurrent Quantification of Cellular and Extracellular Components of Biofilms

Published on: December 10, 2013

Related Experiment Videos

Last Updated: Feb 22, 2026

Purification of a High Molecular Mass Protein in Streptococcus mutans

Purification of a High Molecular Mass Protein in Streptococcus mutans

Published on: September 14, 2019

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Concurrent Quantification of Cellular and Extracellular Components of Biofilms

Concurrent Quantification of Cellular and Extracellular Components of Biofilms

Published on: December 10, 2013

Area of Science:

Microbiology
Dental Science
Infectious Diseases

Background:

Dental caries is a widespread infectious disease caused by Streptococcus mutans.
Current predictors of caries development are insufficient for individual risk assessment.

Purpose of the Study:

To investigate if specific adhesin types of Streptococcus mutans (SpaP, Cnm, Cbm) can predict individual caries development.
To explore the association between adhesin types, host binding (DMBT1, collagen), and caries incidence.

Main Methods:

Quantitative PCR (qPCR) was used to measure adhesin types in whole saliva from 452 Swedish children.
Caries development was assessed at baseline and over a 5-year follow-up period.
Genetic and phenotypic properties of isolated S. mutans strains were analyzed.

Main Results:

The presence of SpaP B and Cnm subtypes correlated with increased 5-year caries increment.
Binding of these adhesins to DMBT1 and saliva was linked to individual caries scores.
SpaP B subtypes showed amino acid substitutions associated with increased acid tolerance and caries.

Conclusions:

Specific adhesin subtypes of Streptococcus mutans (SpaP B, Cnm) serve as reliable predictors of individual caries development.
These findings support the development of individualized oral care strategies based on S. mutans adhesin profiles.