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Role of wild-type p53-induced phosphatase 1 in cancer

Zhi-Peng Wang1, Ye Tian1, Jun Lin1

  • 1Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.

Oncology Letters
|September 30, 2017
PubMed

Insights

Wild-type p53-induced phosphatase (Wip1) is an oncogene that promotes cancer by inhibiting tumor suppressors and DNA damage responses. Targeting Wip1 offers potential for novel cancer therapies and overcoming chemotherapy resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Wild-type p53-induced phosphatase (Wip1) is a protein phosphatase type 2C family member.
  • Wip1 acts as an oncogene by dephosphorylating tumor suppressors and negatively regulating DNA damage response pathways.
  • It dephosphorylates key proteins like p53, ATM, CHK1, and p38 MAPK, creating feedback loops that inhibit apoptosis and cell cycle arrest.

Purpose of the Study:

  • To review the current understanding of Wip1's role in human cancers.
  • To explore Wip1's potential as a diagnostic biomarker and therapeutic target in oncology.
  • To discuss Wip1's emerging function in regulating chemotherapy resistance.

Main Methods:

  • Literature review of existing research on Wip1 in cancer.
  • Analysis of Wip1's molecular mechanisms in tumor suppression and DNA damage.
  • Examination of Wip1's involvement in cancer progression, metastasis, and apoptosis.

Main Results:

  • Wip1 plays a significant role in tumorigenesis, cancer progression, invasion, metastasis, and apoptosis.
  • Wip1 is implicated in the development of resistance to various cancer chemotherapies.
  • Wip1's dephosphorylation activities contribute to its oncogenic functions.

Conclusions:

  • Wip1 is a critical regulator in multiple aspects of cancer biology.
  • Wip1 represents a promising therapeutic target for developing novel anti-cancer strategies.
  • Understanding Wip1's role in chemotherapy resistance may lead to improved treatment outcomes.
Keywords:
canceroncogeneprotein phosphatase magnesium-dependent 1 δwild-type p53-induced phosphatase

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