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Is Andrographis paniculata extract and andrographolide anaphylactic?
Edwin Jothie Richard1, Sasikumar Murugan1, Bharathi Bethapudi1
1Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 560 100, Karnataka, India.
Toxicology Reports
|September 30, 2017
Summary
Andrographis paniculata extract showed no anaphylactic or anaphylactoid potential in animal and cell studies. However, andrographolide, a key compound, demonstrated mild to moderate release of allergic mediators in vitro, warranting further investigation.
Area of Science:
- Pharmacology
- Immunology
- Phytochemistry
Background:
- Andrographis paniculata, known as the "King of Bitters," is widely used medicinally.
- Recent reports suggest potential anaphylactic/allergic adverse events associated with its use.
Purpose of the Study:
- To evaluate the anaphylactic and anaphylactoid potential of Andrographis paniculata extract.
- To assess the effects of andrographolide, a major active compound, on allergic mediator release.
Main Methods:
- Active systemic anaphylaxis (ASA) assay in guinea pigs.
- In vitro studies using IgE-sensitized and non-sensitized Rat Basophilic Leukemia (RBL-2H3) cell lines to measure allergic mediator release.
Main Results:
- Andrographis paniculata extract and andrographolide did not induce anaphylaxis in guinea pigs.
- Andrographis paniculata extract did not cause allergic mediator release from RBL-2H3 cells.
- Andrographolide induced mild to moderate allergic mediator release from RBL-2H3 cells in vitro.
Conclusions:
- Andrographis paniculata extract exhibits no anaphylactic or anaphylactoid potential based on in vivo and in vitro findings.
- The in vitro effects of andrographolide on allergic mediators require further scrutiny for biological significance.
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