Advanced Human Immunodeficiency Virus Disease at Diagnosis in Mozambique and Swaziland

Early diagnosis of human immunodeficiency virus (HIV) is a prerequisite to maximizing individual and societal benefits of antiretroviral therapy.

Adults ≥18 years of age testing HIV positive at 10 health facilities in Mozambique and Swaziland received point-of-care CD4⁺ cell count testing immediately after diagnosis. We examined median CD4⁺ cell count at diagnosis, the proportion diagnosed with advanced HIV disease (CD4⁺ cell count ≤350 cells/μL) and severe immunosuppression (CD4⁺ cell count ≤100 cells/μL), and determinants of the latter 2 measures.

Among 2333 participants, the median CD4⁺ cell count at diagnosis was 313 cells/μL (interquartile range, 164-484), more than half (56.5%) had CD4⁺ ≤350 cells/μL, and 13.9% had CD4⁺ ≤100 cells/μL. The adjusted relative risk (aRR) of both advanced HIV disease and severe immunosuppression at diagnosis was higher in men versus women (advanced disease aRR = 1.31; 95% confidence interval [CI] = 1.16-1.48; severe immunosuppression aRR = 1.54, 95% CI = 1.17-2.02) and among those who sought HIV testing because they felt ill (advanced disease aRR = 1.30, 95% CI = 1.08-1.55; severe immunosuppression aRR = 2.10, 95% CI = 1.35-2.26). Age 18-24 versus 25-39 was associated with a lower risk of both outcomes (advanced disease aRR = 0.70, 95% CI = 0.59-0.84; severe immunosuppression aRR = 0.62, 95% CI = 0.41-0.95).

More than 10 years into the global scale up of comprehensive HIV services, the majority of adults diagnosed with HIV at health facilities in 2 high-prevalence countries presented with advanced disease and 1 in 7 had severe immunosuppression. Innovative strategies for early identification of HIV-positive individuals are urgently needed.