Clevudine Induced Mitochondrial Myopathy
Soo Hyun Park1, Kyung Seok Park2, Nam Hee Kim3
1Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea.
Journal of Korean Medical Science
|September 30, 2017
Summary
Long-term clevudine therapy for hepatitis B may cause reversible mitochondrial myopathy. This condition, characterized by muscle weakness, typically improves after discontinuing the antiviral drug.
Area of Science:
- Hepatology
- Neurology
- Pathology
Background:
- Clevudine is an antiviral effective against hepatitis B virus, generally considered safe.
- However, clevudine-induced myopathy has been reported, necessitating further investigation.
Purpose of the Study:
- To characterize clevudine-induced myopathy by analyzing clinical and pathological findings.
- To assess the safety profile of long-term clevudine use.
Main Methods:
- A comprehensive review of 95 clevudine myopathy cases, including seven new patient cases.
- Analysis of demographic data, clinical manifestations, electromyography, and muscle biopsy results.
Main Results:
- The 95 patients (52 women, 43 men; mean age 48.9 years) developed myopathy after approximately 14.2 months of clevudine therapy.
- Proximal extremity weakness, elevated creatine kinase (97.9%), and myopathic electromyography patterns (98.1%) were common.
- Muscle biopsies predominantly showed mitochondrial myopathy (90.2%).
Conclusions:
- Long-term clevudine therapy (around 14 months) can lead to reversible mitochondrial myopathy.
- Clinical vigilance is crucial for patients undergoing extended clevudine treatment.
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