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Assessment of platelet function on the routine coagulation analyzer Sysmex CS-2000i
Corinne Frère1, Katsushi Kobayashi2, Claire Dunois2
1a Assistance Publique-Hôpitaux de Marseille, Service d'Hématologie Biologique , CHU Timone , Marseille , France.
Platelets
|September 30, 2017
Summary
This study validates the Sysmex CS-2000i for automated platelet aggregation testing, offering a reliable alternative to traditional methods. It provides accurate platelet function assessment for bleeding disorders and antiplatelet therapy response.
Area of Science:
- Hematology
- Clinical Chemistry
- Diagnostic Technology
Background:
- Light transmission aggregometry (LTA) is the gold standard for platelet function testing.
- LTA has limitations including specialized equipment needs, large sample volumes, and time-consuming procedures.
Purpose of the Study:
- To evaluate an automated platelet aggregation method using the Sysmex CS-2000i analyzer.
- To compare the CS-2000i's performance against a reference instrument for platelet function analysis.
Main Methods:
- 46 patients with bleeding syndromes and 62 on dual antiplatelet therapy were studied.
- Platelet aggregation was measured on the Sysmex CS-2000i and APACT-4004 using various agonists (ADP, collagen, epinephrine, ristocetin, arachidonic acid).
- Platelet-rich plasma (PRP) was tested simultaneously on both devices.
Main Results:
- Significant correlations (p<0.001) were found between the CS-2000i and LTA across all stimulations.
- Similar aggregation profiles were observed for patients with bleeding syndromes using both methods.
- High inter-agreement rates (weighted kappa>0.70) were achieved for detecting low responders to antiplatelet agents.
Conclusions:
- Automated platelet aggregation on the Sysmex CS-2000i is a reliable and accessible tool.
- This method overcomes many limitations associated with traditional LTA.
- It offers a rapid and standardized approach for assessing platelet function.
