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Updated: Feb 22, 2026

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Structural asymmetry in the eukaryotic Elongator complex.

Maria I Dauden1, Marcin Jaciuk2, Christoph W Müller1

  • 1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

FEBS Letters
|September 30, 2017
PubMed
Summary
This summary is machine-generated.

The Elongator complex, crucial for protein synthesis, has an asymmetric structure that impacts its function. Mutations in its subunits are linked to severe human diseases, highlighting its importance.

Keywords:
Elongatorelectron microscopytRNA modification

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Nucleoside modifications in transfer RNA (tRNA) anticodons are vital for regulating protein synthesis.
  • The eukaryotic Elongator complex is responsible for specific modifications of uridines in tRNA wobble bases.
  • This complex consists of six subunits, each present in two copies and essential for its catalytic activity.

Purpose of the Study:

  • To review recent findings on the Elongator complex's architecture and functional consequences.
  • To explore the roles of the proposed active site, individual subunits, and associated regulatory factors.
  • To offer mechanistic insights into how Elongator subunit mutations lead to human diseases.

Main Methods:

  • Structural analysis of the Elongator complex.
  • Biochemical assays to study enzyme activity.
  • Genetic studies linking mutations to disease phenotypes.

Main Results:

  • The Elongator complex exhibits an asymmetric subunit arrangement.
  • This architecture is crucial for its role in tRNA modification and protein synthesis regulation.
  • Specific mutations in Elongator subunits are associated with human pathologies.

Conclusions:

  • The asymmetric structure of the Elongator complex is key to its function in fine-tuning protein synthesis.
  • Understanding the Elongator complex's mechanisms provides insights into human diseases.
  • Further research into Elongator subunits and regulatory factors is warranted.