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Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
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Related Experiment Video

Updated: Feb 22, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

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Migraine and Yawning.

Bülent Güven1, Hayat Güven1, Selim Selçuk Çomoğlu1

  • 1Department of Neurology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Headache
|September 30, 2017
PubMed
Summary
This summary is machine-generated.

Repetitive yawning is a common symptom during migraine attacks, occurring in 45.4% of patients. This behavior is linked to migraine with aura and symptoms like nausea and vomiting, suggesting potential for early migraine detection.

Keywords:
dopaminehypothalamusmigraineyawning

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Area of Science:

  • Neurology
  • Neuroscience
  • Dopaminergic Activity

Background:

  • Yawning is linked to dopaminergic activity, but its role in migraine pathophysiology is unclear.
  • Repetitive yawning is observed in some migraine patients during attacks.
  • This study investigates yawning frequency and its associations in migraine.

Purpose of the Study:

  • To determine the frequency of yawning during migraine attacks.
  • To explore the association between yawning and migraine characteristics.
  • To identify yawning as a potential early indicator for migraine treatment.

Main Methods:

  • A cross-sectional study involving 339 migraine patients.
  • Patients completed questionnaires and diaries detailing headache characteristics and symptoms.
  • Repetitive yawning was recorded in the premonitory phase and/or during headache episodes.

Main Results:

  • 45.4% of patients reported repetitive yawning during migraine attacks.
  • Yawning was more frequent in migraine with aura (46.8%) and associated with nausea (89.6%), vomiting (48.7%), osmophobia (66.7%), and cutaneous allodynia (58.2%).
  • Nausea (OR 2.88) and migraine with aura (OR 1.66) significantly increased the odds of repetitive yawning.

Conclusions:

  • Yawning is a common symptom preceding or accompanying migraine attacks.
  • Yawning is significantly associated with migraine with aura, nausea/vomiting, osmophobia, and cutaneous allodynia.
  • Yawning serves as a unique and reliable indicator for early migraine intervention.