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Published on: April 20, 2011
Genetic characterization of enterovirus A71 isolates from severe neurological cases in Poland
Magdalena Wieczorek1, Mariola Purzyńska2, Arleta Krzysztoszek1
1Department of Virology, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.
Abstract:
The aim of this study was to report a minor outbreak of enterovirus A71 (EV-A71) infection in Poland and characterize isolates from cases of severe neurological infection detected in 2013 and 2016. Phylogenetic analysis revealed that Polish strains belonged to the C genogroup: C1, C2, and C4. Severe neurological manifestations as encephalitis or acute flaccid paralysis (AFP), were associated with all detected subgenogroups. The C2 subgenogroup was associated with the outbreak in Gdansk, with serious cases of AFP, myelitis, cerebellitis, encephalitis, but also with mild, sporadic cases of aseptic meningitis, in other Polish cities. Data from the study established relationships of EV-A71 from Poland with previously characterized strains and confirmed the importance of high quality enterovirus surveillance with international reach.
Insights
Enterovirus A71 (EV-A71) caused a minor outbreak in Poland, leading to severe neurological infections like encephalitis and acute flaccid paralysis (AFP). Phylogenetic analysis identified C genogroups, highlighting the need for robust global enterovirus surveillance.
Area of Science:
- Virology
- Infectious Diseases
- Epidemiology
Background:
- Enterovirus A71 (EV-A71) is a significant cause of neurological disease in children.
- Outbreaks of EV-A71 have been reported globally, necessitating ongoing surveillance.
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