Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)

Area of Science:

• Structural biology
• Computational biology
• Biochemistry

Background:

• The Critical Assessment of protein Structure Prediction (CASP) experiment evaluates computational methods for protein structure prediction.
• CASP12 focused on assessing the accuracy of predicted protein structures against experimentally determined ones.

Purpose of the Study:

• To describe the functional and biological significance of selected CASP12 targets.
• To analyze interesting structural features of target proteins.
• To evaluate the accuracy of predicted structures submitted to CASP12.

Main Methods:

• Analysis of structural features of target proteins.
• Comparison of predicted protein structures with experimentally determined structures from CASP12.

Main Results:

• Detailed descriptions of the functional and biological significance of CASP12 targets.
• Identification and discussion of key structural features in the target proteins.
• Assessment of the accuracy of structure predictions submitted to CASP12.

Conclusions:

• The study provides insights into the biological relevance of specific protein targets.
• Structural features critical for protein function were identified.
• The accuracy of computational structure prediction methods in CASP12 was evaluated based on structural reproduction.