Related Experiment Video

Updated: Feb 22, 2026

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry
08:04

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry

Published on: March 13, 2014

12.7K

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)

Andriy Kryshtafovych1, Reinhard Albrecht2, Arnaud Baslé3

  • 1Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California, 95616.

Proteins
|September 30, 2017
PubMed

Insights

This study examines the functional significance of CASP12 targets by analyzing their structural features. Researchers assessed how well predicted protein structures matched experimentally determined ones in the CASP12 experiment.

Area of Science:

  • Structural biology
  • Computational biology
  • Biochemistry

Background:

  • The Critical Assessment of protein Structure Prediction (CASP) experiment evaluates computational methods for protein structure prediction.
  • CASP12 focused on assessing the accuracy of predicted protein structures against experimentally determined ones.

Purpose of the Study:

  • To describe the functional and biological significance of selected CASP12 targets.
  • To analyze interesting structural features of target proteins.
  • To evaluate the accuracy of predicted structures submitted to CASP12.

Main Methods:

  • Analysis of structural features of target proteins.
  • Comparison of predicted protein structures with experimentally determined structures from CASP12.

Main Results:

  • Detailed descriptions of the functional and biological significance of CASP12 targets.
  • Identification and discussion of key structural features in the target proteins.
  • Assessment of the accuracy of structure predictions submitted to CASP12.

Conclusions:

  • The study provides insights into the biological relevance of specific protein targets.
  • Structural features critical for protein function were identified.
  • The accuracy of computational structure prediction methods in CASP12 was evaluated based on structural reproduction.
Keywords:
CASPNMRX-ray crystallographyprotein structure prediction

More Related Videos

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.9K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.8K

Related Concept Videos

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
14.3K
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.8K