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A Smart Metal-Organic Framework Nanomaterial for Lung Targeting
Teresa Simon-Yarza1,2, Mónica Giménez-Marqués1,3, Rhizlaine Mrimi1
1Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035, Versailles, University Paris Saclay, France.
Angewandte Chemie (International Ed. in English)
|September 30, 2017
Summary
Nanosized metal-organic frameworks (nanoMOFs) target lung tissue by aggregating in blood and disaggregating in the lungs. This novel approach shows potential for effective lung cancer drug delivery without surface modification.
Area of Science:
- Nanotechnology
- Materials Science
- Oncology
Background:
- Lung diseases present significant morbidity and mortality.
- Effective drug delivery to lung tissue remains a challenge.
- Existing particle-based lung targeting methods face toxicity concerns.
Purpose of the Study:
- To explore the potential of nanosized metal-organic frameworks (nanoMOFs) for passive lung targeting and drug delivery.
- To investigate the antitumoral effects of nanoMOFs on experimental lung tumors.
- To overcome toxicity issues associated with long-term particle presence in the lungs.
Main Methods:
- Utilized pH-responsiveness and reversible aggregation properties of nanoMOFs.
- Investigated nanoMOF behavior in neutral blood pH and lung tissue.
- Assessed drug payload release and compatibility with lung physiology.
Main Results:
- NanoMOFs demonstrated impressive antitumoral effects on experimental lung tumors without surface engineering.
- NanoMOFs aggregated at neutral blood pH, enabling retention in lung capillaries.
- NanoMOFs disaggregated within 24 hours, releasing their drug payload in a manner compatible with lung tissue.
Conclusions:
- NanoMOFs possess inherent lung-targeting capabilities based on their physicochemical properties.
- This pH-responsive aggregation and disaggregation mechanism offers a promising strategy for lung drug delivery.
- The approach overcomes previous limitations, showing potential for improved lung cancer treatment.
