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Special Issue: Sulfonamides
1Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, I-50019 Sesto Fiorentino (Florence), Italy. claudiu.supuran@unifi.it.
Molecules (Basel, Switzerland)
|September 30, 2017
Summary
Sulfonamides and related compounds like sulfamates and sulfamides share a core structure. These versatile chemical entities are linked to various molecular scaffolds, impacting their properties and applications.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
Background:
- Sulfonamides, sulfamates, and sulfamides are key nitrogen- and sulfur-containing organic compounds.
- These compounds share the general formula A-SO2NHR, featuring a sulfonamide functional group.
Discussion:
- The sulfonamide functional group can be directly attached to diverse scaffolds (aromatic, heterocyclic, aliphatic, sugar).
- Alternatively, it can be linked via heteroatoms like oxygen or nitrogen, forming sulfamates and sulfamides.
Key Insights:
- The structural diversity of sulfonamide derivatives allows for a wide range of chemical properties.
- Understanding these structural variations is crucial for designing new molecules.
Outlook:
- Further exploration of sulfonamide derivatives could lead to novel therapeutic agents.
- Investigating structure-activity relationships will be key for future drug discovery efforts.
