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Updated: Feb 22, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances
Tecla Gasperi1, Martina Miceli2, Jean-Marc Campagne3
1Dipartimento di Scienze, Sezione di Nanoscienze e Nanotecnologie, Università degli Studi Roma Tre, via della Vasca Navale 79, I-00146 Roma, Italy. tecla.gasperi@uniroma3.it.
Abstract:
The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities. Expansion and refinement in the field of asymmetric organocatalysis have made possible the development of straightforward strategies that address these two requisites. In this review, we illustrate the current state-of-the-art in the field of spirooxindole synthesis through the use of non-covalent organocatalysis. We aim to provide a concise overview of very recent methods that allow to the isolation of unique, densely and diversified spirocyclic oxindole derivatives with high structural diversity via the use of cascade, tandem and domino processes.
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