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Accessing the Subdural Space of the Rodent Spinal Cord for Treatment Delivery
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Intrathecal Therapeutics: Device Design, Access Methods, and Complication Mitigation.

Sean J Nagel1, Chandan G Reddy2, Leonardo A Frizon1

  • 1Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA.

Neuromodulation : Journal of the International Neuromodulation Society
|September 30, 2017
PubMed
Summary

The intrathecal space offers significant potential for diagnostics and therapeutics but is underutilized. Advances in hardware and techniques are poised to expand its clinical application.

Keywords:
Intrathecal deliveryspinal canalspinal cordspinal cord stimulationthecal sac

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Area of Science:

  • Neurological Surgery
  • Biomedical Engineering
  • Neurosurgical Devices

Background:

  • The intrathecal space is underutilized for diagnostics, monitoring, and therapeutic delivery due to unfamiliarity and historical risks.
  • Current intrathecal devices face limitations in design and functionality.

Purpose of the Study:

  • To review current intrathecal access devices and assess associated risks.
  • To propose a research model for next-generation intrathecal hardware.

Main Methods:

  • Literature review of historical and contemporary intrathecal access devices and catheters.
  • Assessment of implantation risks and complications.

Main Results:

  • Few intrathecal devices are marketed, typically with fixed designs and limited steerability.
  • Complications are rare with current recommended techniques.
  • Existing devices prioritize durability and ease of use over advanced features.

Conclusions:

  • Future advances in catheter design, access techniques, and imaging will enhance the intrathecal space's value.
  • The intrathecal space is expected to become a key target for diagnostics and therapeutics.
  • Concurrent advancements will accelerate the adoption of new intrathecal technologies.