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Recent Progress in Near Infrared Light Triggered Photodynamic Therapy
Kerong Deng1,2, Chunxia Li3, Shanshan Huang1
1School of Applied Physics and Materials, Wuyi University, Jiangmen, Guangdong, 529020, China.
Small (Weinheim an Der Bergstrasse, Germany)
|September 30, 2017
Summary
Near-infrared (NIR) light-triggered photodynamic therapy (PDT) offers deeper tumor penetration and less damage than conventional PDT. This review covers advancements in NIR-activated PDT nanosystems for improved cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Photodynamic therapy (PDT) is a promising cancer treatment modality.
- Conventional PDT uses UV or visible light, limiting its effectiveness for deep-seated tumors.
- Near-infrared (NIR) light offers deeper tissue penetration and reduced photodamage, making it ideal for in vivo applications.
Purpose of the Study:
- To review recent research on NIR light-responsive PDT nanosystems.
- To summarize innovative strategies addressing PDT limitations.
- To discuss future prospects and challenges in NIR-PDT development.
Main Methods:
- Review of recent scientific literature on NIR-PDT nanosystems.
- Analysis of strategies like targeted moieties, oxygen-independent PDT, dual photosensitizers, and synergistic therapy.
- Discussion of challenges and future directions.
Main Results:
- NIR light-responsive PDT nanosystems show significant potential for deep-seated tumor treatment.
- Innovative strategies enhance PDT efficacy and overcome current obstacles.
- Targeted moieties, O2 self-sufficient PDT, dual photosensitizers, and synergistic therapies are key advancements.
Conclusions:
- NIR-PDT nanosystems represent a significant advancement in cancer therapy.
- Further development is needed to address challenges and fully realize the potential of NIR-PDT.
- The reviewed strategies offer promising avenues for more effective and targeted cancer treatments.
