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Updated: Feb 22, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
3DBIONOTES v2.0: a web server for the automatic annotation of macromolecular structures
Joan Segura1, Ruben Sanchez-Garcia1, Marta Martinez1
1GN7 of the Spanish National Institute for Bioinformatics (INB), Biocomputing Unit, National Center of Biotechnology (CSIC), Instruct Image Processing Center, Madrid 28049, Spain.
Motivation:
Complementing structural information with biochemical and biomedical annotations is a powerful approach to explore the biological function of macromolecular complexes. However, currently the compilation of annotations and structural data is a feature only available for those structures that have been released as entries to the Protein Data Bank.
Results:
To help researchers in assessing the consistency between structures and biological annotations for structural models not deposited in databases, we present 3DBIONOTES v2.0, a web application designed for the automatic annotation of biochemical and biomedical information onto macromolecular structural models determined by any experimental or computational technique.
Availability And Implementation:
The web server is available at http://3dbionotes-ws.cnb.csic.es.
Contact:
jsegura@cnb.csic.es.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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