Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

90.1K
Overview
90.1K
Human Genetics01:28

Human Genetics

1.7K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.7K
Phylogeny01:23

Phylogeny

63.1K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
63.1K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

76.7K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
76.7K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Punnett Squares01:00

Punnett Squares

126.3K
Overview
126.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Familial medullary thyroid carcinoma secondary to an <i>SLC30A9</i> intragenic deletion and translation reinitiation.

medRxiv : the preprint server for health sciences·2026
Same author

Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging.

Nature communications·2025
Same author

Galaxy single-cell & spatial omics community update: Navigating new frontiers in 2025.

Cell genomics·2025
Same author

Fifty Shades of Risk: Population Studies and the Genetic Architecture of Kidney Diseases.

Journal of the American Society of Nephrology : JASN·2025
Same author

TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors.

Cell reports·2025
Same author

Rare disease gene association discovery in the 100,000 Genomes Project.

Nature·2025

Related Experiment Video

Updated: Feb 22, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.6K

HaploForge: a comprehensive pedigree drawing and haplotype visualization web application.

Mehmet Tekman1, Alan Medlar2, Monika Mozere1

  • 1Division of Medicine, University College London, London NW3 2PF, UK.

Bioinformatics (Oxford, England)
|September 30, 2017
PubMed
Summary
This summary is machine-generated.

HaploForge is a new web application that visualizes genetic haplotypes and pedigrees, overcoming limitations of existing tools for large datasets and X-chromosome analysis. It offers accurate, portable, and fast visualization for complex genetic studies.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.5K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

4.0K

Related Experiment Videos

Last Updated: Feb 22, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.6K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.5K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

4.0K

Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Haplotype reconstruction is crucial for understanding human disease aetiology and trait locus transmission.
  • Existing haplotype visualization tools struggle with large numbers of markers and can produce artefacts for X-chromosome analysis.
  • Inefficient visualization hinders the tracking of haplotypes across generations.

Purpose of the Study:

  • To develop a novel web application, HaploForge, for efficient and accurate haplotype visualization and pedigree drawing.
  • To address the scalability and accuracy issues of existing haplotype visualization software.
  • To provide a user-friendly tool for analyzing complex genetic data.

Main Methods:

  • Developed HaploForge as a portable HTML5 web application, eliminating the need for local installation.
  • Implemented a novel A* search algorithm for coloring haplotypes based on identity by descent.
  • Ensured compatibility with output from popular haplotype reconstruction software (Allegro, GeneHunter, Merlin, Simwalk).

Main Results:

  • HaploForge accurately visualizes autosomal and X-linked haplotypes in both outbred and consanguineous pedigrees.
  • The application is fast, portable, and features a flexible viewing mode for enhanced visual inspection.
  • Successfully processed haplotype reconstruction output from multiple established software packages.

Conclusions:

  • HaploForge offers a significant improvement for haplotype visualization, particularly for large datasets and complex pedigrees.
  • The tool enhances the study of genetic disease aetiology by providing accurate and scalable haplotype analysis.
  • HaploForge is freely available under GPLv3 license, promoting wider adoption in genetic research.