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Value of shared preclinical safety studies - The eTOX database

Katharine Briggs1, Chris Barber1, Montserrat Cases2

  • 1Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds LS11 5PS, United Kingdom.

Toxicology Reports
|October 1, 2017
PubMed

Keywords:
ALP, alkaline phosphataseALT, alanine aminotransferaseAST, aspartate aminotransferaseBiomarkersCDISC, Clinical Data Interchange Standards ConsortiumCRO, contract research organisationDILI, drug induced liver injuryData miningData sharingEFPIA, European Federation of Pharmaceutical Industries and AssociationsFN, false negativeFP, false positiveGLP, good laboratory practiceICH, International Conference on HarmonisationIMI, Innovative Medicines InitiativeINHAND, International Harmonization of Nomenclature and Diagnostic CriteriaIT, information technologyMCC, Matthews correlation coefficientOECD, Organisation for Economic Co-operation and DevelopmentOntologyPDF, Portable Document FormatPDF/A, ISO-standardized version of PDF specialized for the digital preservation of electronic documents.QA, quality assuranceSEND, Standard for Exchange of Nonclinical DataSME, small-to-medium enterpriseTN, true negativeTP, true positiveToxicologyULN, upper limit of normaleTOX, integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities

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