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Updated: Feb 22, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
11:38

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

12.8K

Toxicological evaluation of a novel cooling compound:

Donald S Karanewsky1, Amy J Arthur1, Hanghui Liu1

  • 1Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, USA.

Toxicology Reports
|October 1, 2017
PubMed

Keywords:
AUC, area under the curveCL, plasma clearanceCYP450, cytochrome P450Cmax, peak plasma concentrationCooling agentFDA, Food and Drug AdministrationFEMA GRASFEMA, Flavour and Extract Manufacturers Association of the United StatesGMP, Good Manufacturing PracticesGenetic toxicological evaluationHPBL, human peripheral blood lymphocytesJV, jugular veinLC/MS, liquid chromatography with mass spectrometryMC, methylcelluloseNOAEL, no-observed-adverse-effect-levelNOEL, no-observed-effect-levelOECD, Organization for Economic Cooperation and DevelopmentPCE, polychromatic erythrocytesPK, pharmacokineticsPV, portal veinRCG, Relative Cell GrowthRMI, Relative Mitotic IndexS2227Subchronic toxicological evaluationTE, total erythrocytesTK, toxicokineticsTRPM8, transient receptor potential melastatin 8Tmax, time to reach CmaxVss, volume of distribution at steady-statemnPCE, micronucleated bone marrow polychromatic erythrocytest1/2, half-life

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