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DNA methylation-mediated silencing of FLT1 in parthenogenetic porcine placentas

Yuning Song1, Zhiquan Liu1, Yang Han1

  • 1Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun 130062, China.

Placenta
|October 1, 2017
PubMed

Studies show that perturbed expression of vascular endothelial growth factor (VEGF) family genes is related to abnormal development of parthenogenetic (PA) placenta. In this study, the methylation status of VEGF family genes were compared between PA and normal placentas using bisulfite sequencing PCR (BSP). Results showed no significant difference in the methylation of VEGF-A differentially methylated region (DMR), placental growth factor (PIGF) DMR, and kinase insert domain receptor (KDR) DMR, whereas FMS-like tyrosine kinase 1 (FLT1) DMR was hypermethylated in PA placentas. These results suggested that abnormal methylation of FLT1 DMR might trigger the developmental failure of porcine PA placentas.

Keywords:
DNA methylationFLT1KDRPIGFParthenogeneticVEGF-A

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