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The convergent roles of the nuclear factor I transcription factors in development and cancer

Kok-Siong Chen1, Jonathan W C Lim1, Linda J Richards2

  • 1Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.

Cancer Letters
|October 1, 2017
PubMed

Insights

Nuclear factor I (NFI) transcription factors are crucial for development and implicated in human abnormalities. This review explores their dual role in both normal development and cancer, highlighting their oncogenic or tumor-suppressive potential.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • Nuclear factor I (NFI) transcription factors (NFIA, NFIB, NFIC, NFIX) regulate cell proliferation and differentiation.
  • NFI genes are involved in normal development and human developmental abnormalities.
  • Recent studies link NFI genes to various cancers across multiple organ systems.

Purpose of the Study:

  • To review the converging roles of NFI genes in development and cancer.
  • To summarize evidence on the oncogenic or tumor-suppressive potential of NFI genes in different cancer types.
  • To identify challenges in understanding NFI function in cancer biology and propose a developmental perspective.

Main Methods:

  • Literature review of studies implicating NFI genes in development and cancer.
  • Analysis of genomic data and animal models related to NFI genes in tumors.
  • Synthesis of evidence on NFI gene function, focusing on oncogenic or tumor-suppressive roles.

Main Results:

  • NFI genes exhibit dual roles, acting as oncogenes or tumor suppressors in various cancers.
  • Evidence suggests a link between NFI gene functions in development and their roles in cancer.
  • Specific cancer types where NFI genes are implicated are detailed, with emphasis on their functional potential.

Conclusions:

  • A developmental perspective is crucial for understanding NFI gene function in cancer biology.
  • Further research is needed to overcome challenges in elucidating NFI's role in oncogenesis.
  • NFI transcription factors represent a potential area for therapeutic strategies in cancer treatment.
Keywords:
DevelopmentNFINuclear factor INuclear factor oneTranscription factorTumorigenesis

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