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Challenging cancer targets for aptamer delivery
1Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy.
Biochimie
|October 1, 2017
Summary
RNA therapeutics offer new cancer treatment hope. Aptamers, or nucleic acid antibodies, are emerging as precise carriers for these therapies, overcoming delivery challenges to target cancer cells effectively.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Advances in understanding cancer genetics and epigenetics fuel precise therapeutic development.
- RNA-based therapeutics show promise but face systemic delivery challenges, especially to solid tumors.
- Effective delivery requires carriers to overcome biological barriers and target cancer cells intracellularly.
Purpose of the Study:
- To review recent progress in aptamer-based delivery systems for cancer gene therapy.
- To highlight the potential of aptamer-RNA conjugates as precise and effective anticancer therapeutics.
- To discuss the challenges and future directions in aptamer-mediated drug delivery.
Main Methods:
- Review of recent scientific literature on aptamer applications in cancer gene therapy.
- Analysis of aptamer-target interactions and in vivo delivery strategies.
- Focus on aptamer-based chimeras for targeted RNA therapeutic delivery.
Main Results:
- Nucleic acid aptamers demonstrate high affinity and specificity for various targets.
- Aptamers can facilitate receptor-mediated cellular uptake and intracellular targeting of therapeutics.
- Aptamer-RNA conjugates show potential for overcoming systemic delivery barriers in cancer therapy.
Conclusions:
- Aptamers are emerging as versatile targeting moieties for RNA-based cancer gene therapeutics.
- Aptamer-based strategies offer precision and flexibility in overcoming drug delivery challenges.
- Further development of aptamer chimeras holds promise for safe and effective cancer treatment.
Keywords:
AptamersBlood brain barrierCancer stem cellsGene editingGene therapyTherapeutic RNA deliveryMore Related Videos
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