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The interaction between mitochondria and oncoviruses

Shujie Song1, Shasha Gong2, Pragya Singh3

  • 1Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|October 1, 2017
PubMed

Insights

Mitochondria are crucial in viral cancer development, influencing host genetics and cellular processes. Viruses hijack mitochondria, altering energy production and signaling to promote oncogenesis by viruses like HBV and HPV.

Area of Science:

  • Mitochondrial biology
  • Virology
  • Oncogenesis

Background:

  • Mitochondria are vital organelles involved in cellular energy production and signaling.
  • Mitochondrial genomes contribute to the host's genetic makeup.
  • Viral infections can significantly impact host cell mitochondria.

Purpose of the Study:

  • To explore the multifaceted roles of mitochondria in viral tumorigenesis.
  • To discuss how viruses modulate mitochondrial functions to promote cancer.
  • To examine oncogenesis mediated by specific oncoviruses.

Main Methods:

  • Literature review and synthesis of existing research on mitochondria and viral oncogenesis.
  • Analysis of the impact of viral infections on mitochondrial bioenergetics.
  • Examination of retrograde signaling pathways affected by viruses.

Main Results:

  • Viruses modulate mitochondrial function, affecting host bioenergetics and signaling.
  • Mitochondria are integral to the mechanisms of viral oncogenesis.
  • Specific oncoviruses (HBV, HCV, HPV, HIV, EBV) utilize mitochondrial pathways for tumor promotion.

Conclusions:

  • Mitochondria are key players in the development of virus-associated cancers.
  • Understanding mitochondrial-viral interactions is critical for targeting viral oncogenesis.
  • Targeting mitochondrial pathways may offer novel therapeutic strategies against viral cancers.
Keywords:
EBVHBVHCVHIVHPVMitochondriaOncovirus

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