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New phloroglucinol derivatives from the whole plant of Hypericum uralum
Xiaoqing Li1, Yun Li1, Jianguang Luo1
1Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Abstract:
Seven new phloroglucinol derivatives, uraliones L-R (1-7), were isolated from the whole plant of Hypericum urialum. The structures of new compounds were unambiguously elucidated by comprehensive spectroscopic analysis, and the absolute configurations of the vic-diol groups were determined by Mo2(OAc)4-induced electronic circular dichroism experiments. Their capability to reversal the multidrug resistance in doxorubicin-induced resistant MCF-7/DOX sublines showed that compounds 1, 5, 6, 7 exerted a potential effect of doxorubicin susceptibility.
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