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Intracranial Aneurysms in Adult Moyamoya Disease

Jang Hun Kim1, Taek-Hyun Kwon1, Jong Hyun Kim1

  • 1Department of Neurosurgery, Guro Hospital, Korea University College of Medicine, Seoul, Korea.

World Neurosurgery
|October 1, 2017
PubMed
Abstract

Insights

Moyamoya disease (MMD) patients with intracranial aneurysms have an 8.3% prevalence and a high 63.6% rupture rate. These aneurysms, often dissecting or hemodynamic, are linked to hemorrhagic MMD and hemodynamic stress.

Area of Science:

  • Neurology
  • Neurosurgery
  • Vascular Neurology

Background:

  • Moyamoya disease (MMD) presents a significant risk of intracranial aneurysm formation, affecting approximately 14% of adults.
  • Intracranial aneurysms in MMD patients pose a major hemorrhagic risk.
  • Understanding MMD-associated aneurysms is crucial for managing patient outcomes.

Purpose of the Study:

  • To investigate the specific characteristics of intracranial aneurysms in patients diagnosed with Moyamoya disease.
  • To compare clinical and imaging features between MMD patients with and without intracranial aneurysms.

Main Methods:

  • Retrospective review of 211 patients with MMD between 2007 and 2016.
  • Categorization of patients into groups with and without intracranial aneurysms.
  • Statistical analysis of demographic and clinical data, alongside review of angiographic findings.

Main Results:

  • Prevalence of intracranial aneurysms in MMD patients was 8.3% (11 of 132 patients).
  • A high rupture rate of 63.6% was observed for these MMD-associated aneurysms.
  • Classified aneurysms included 4 dissecting/pseudoaneurysms and 6 hemodynamic true aneurysms.

Conclusions:

  • MMD-associated intracranial aneurysms are common in patients with hemorrhagic MMD.
  • These aneurysms exhibit an extremely high rupture rate.
  • Pathologic, anatomic, and hemodynamic factors likely contribute to aneurysm formation in MMD.
Keywords:
Intracranial aneurysmMoyamoya diseaseMoyamoya-associated aneurysmPseudoaneurysm

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