Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

General Structure of a Vertebra

General Structure of a Vertebra

A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First Report of Leaf Spot Disease on <i>Cinnamomum camphora</i> (Camphor Tree) Caused by <i>Epicoccum poaceicola</i> in China.

Plant disease·2021

Same author

Efficacy of acupuncture in refractory irritable bowel syndrome: study protocol for a randomised controlled trial.

BMJ open·2021

Same author

Assessment of PD-L1 Expression on Circulating Tumor Cells for Predicting Clinical Outcomes in Patients with Cancer Receiving PD-1/PD-L1 Blockade Therapies.

The oncologist·2021

Same author

Defects of monolayer PbI<sub>2</sub>: a computational study.

Physical chemistry chemical physics : PCCP·2021

Same author

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery.

Frontiers in cellular neuroscience·2021

Same author

Study of comparative surgical exposure to the petroclival region using patient-specific, petroclival meningioma virtual reality models.

Neurosurgical focus·2021

Search research articles

Related Experiment Video

Updated: Feb 22, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Lymphoblastic Lymphoma Involving Multiple Vertebrae.

Da Li¹, Yu-Lun Xu¹, Zhen Wu¹

¹Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

World Neurosurgery

|October 1, 2017

Summary

This case study highlights a rare adult presentation of B-cell acute lymphoblastic lymphoma initially involving the epidural compartment. Early diagnosis and treatment led to partial recovery in a young male patient.

Keywords:

Intraspinal epidural tumor Leukemia Lymphoblastic lymphoma Spine

Related Experiment Videos

Last Updated: Feb 22, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

Hematology
Oncology
Neurology

Background:

Acute lymphoblastic lymphoma (ALL) is a common childhood malignancy but rarely presents initially in the epidural space in adults.
Adult-onset epidural ALL is an uncommon entity, posing diagnostic challenges due to its rarity and potential for mimicking other spinal pathologies.

Observation:

A 20-year-old male presented with progressive low back pain and constipation, symptoms suggestive of spinal cord compression.
Magnetic resonance imaging revealed multiple vertebral lesions and an intraspinal epidural mass, prompting further investigation.
Histopathology confirmed a high-grade malignant B-cell lymphoma with a high proliferation index (Ki-67 90%) and CD45 (leukocyte common antigen) positivity.

Findings:

A bone marrow biopsy definitively diagnosed B-cell acute lymphoblastic lymphoma.
The patient underwent subtotal resection of the epidural lesion followed by chemotherapy, including methotrexate.
Partial recovery of symptoms was observed post-treatment, indicating a positive response to therapy.

Implications:

This case underscores the importance of considering rare diagnoses like epidural ALL in young adults presenting with spinal symptoms.
Bone marrow biopsy is crucial for definitive diagnosis, especially in the absence of hypercalcemia or peripheral blood abnormalities.
Multimodality treatment involving surgery and chemotherapy can lead to favorable outcomes even in rare presentations of ALL.