The Bone Marrow Microenvironment in Health and Myeloid Malignancy

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Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
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Marta Galán-Díez1, Álvaro Cuesta-Domínguez1, Stavroula Kousteni1

  • 1Department of Physiology & Cellular Biophysics, College of Physicians & Surgeons, Columbia University, New York, New York 10032.

Cold Spring Harbor Perspectives in Medicine
|October 1, 2017
PubMed

Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the bone marrow (BM) microenvironment or niche. These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quiescence. They also contribute to hematopoietic deregulation and hematological myeloid malignancies. Alterations in the BM niche are commonly observed in myeloid malignancies and contribute to the aberrant function of myelodysplastic and leukemia-initiating stem cells. In this work, we review how different components of the BM niche affect normal hematopoiesis, the molecular signals that govern this interaction, and how genetic changes in stromal cells or alterations in remodeled malignant BM niches contribute to myeloid malignancies. Understanding the intricacies between normal and malignant niches and their modulation may provide insights into developing novel therapeutics for blood disorders.

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