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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: Feb 22, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

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Can Osteoarthritis Predict Mortality?

Rebecca J Cleveland1, Leigh F Callahan2

  • 1research assistant professor, Thurston Arthritis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina becki@unc.edu.

North Carolina Medical Journal
|October 1, 2017
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) is a common musculoskeletal condition. Its increasing prevalence due to aging and obesity highlights the need to understand its impact on mortality.

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Area of Science:

  • Rheumatology
  • Epidemiology
  • Public Health

Background:

  • Osteoarthritis (OA) is the most prevalent musculoskeletal disorder globally.
  • Increasing global obesity rates and an aging population are driving a significant rise in OA.
  • OA is linked to disability and comorbidities like diabetes and cardiovascular disease.

Purpose of the Study:

  • To examine the association between osteoarthritis and mortality.
  • To understand the public health implications of osteoarthritis, considering its impact on lifespan.

Main Methods:

  • This study reviews existing literature on osteoarthritis prevalence and mortality data.
  • Epidemiological data on aging populations and obesity trends were analyzed.
  • Comorbidity data linking osteoarthritis to chronic conditions were assessed.

Main Results:

  • Osteoarthritis prevalence is projected to increase substantially worldwide.
  • The condition is associated with significant disability and chronic health issues.
  • The impact of osteoarthritis on mortality requires further investigation.

Conclusions:

  • Given its widespread nature and associated health risks, the mortality impact of osteoarthritis warrants serious consideration.
  • Public health strategies must address the growing burden of osteoarthritis and its contribution to mortality.
  • Further research is needed to quantify the precise relationship between osteoarthritis and mortality risk.