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Antihistone Autoantibodies in Dobermans With Hepatitis
H Dyggve1,2, S Meri2, T Spillmann1
1Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Journal of Veterinary Internal Medicine
|October 1, 2017
Summary
Antihistone antibodies (AHA) are significantly elevated in Doberman hepatitis (DH), suggesting an autoimmune basis for the disease. AHA may aid in screening Dobermans with suspected DH.
Area of Science:
- Veterinary Immunology
- Canine Pathology
Background:
- Doberman hepatitis (DH) is suspected to have immune system involvement.
- Evidence includes female predisposition, lymphocyte infiltration, and MHC class II antigen expression.
Purpose of the Study:
- Measure serum antinuclear antibodies (ANA) and antihistone antibodies (AHA) in Dobermans with hepatitis.
- Determine if ANA or AHA can support DH diagnosis.
Main Methods:
- Case-control study involving 25 subclinical DH, 13 clinical DH, and 17 healthy Dobermans.
- Indirect immunofluorescence (IIF) for ANA and ELISA for IgG AHA detection.
Main Results:
- Increased AHA concentrations found in 92% of subclinical and 85% of clinical DH dogs.
- Significantly higher mean AHA absorbance in DH dogs compared to controls (P < 0.0001).
Conclusions:
- Results support an autoimmune background as a cause of DH.
- Antihistone antibodies may offer a novel screening method for DH in Dobermans.
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