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Updated: Feb 22, 2026

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A Tale of Two Elabela Null Mice.

Irinna Papangeli1, Hyung J Chun1

  • 1Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.

Trends in Endocrinology and Metabolism: TEM
|October 2, 2017
PubMed
Summary

Elabela (ELA), a peptide crucial for development in lower vertebrates, is vital for mammalian embryogenesis and cardiovascular health. Studies on Ela null mice reveal severe developmental defects, highlighting its role in cardiometabolic pathways.

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Area of Science:

  • Developmental Biology
  • Cardiovascular Science
  • Endocrinology

Background:

  • Elabela (ELA) is a peptide ligand for the apelin receptor (APLNR).
  • ELA is essential for endoderm and cardiac development in lower vertebrates.
  • The role of ELA in mammalian development and cardiometabolic pathways requires further investigation.

Purpose of the Study:

  • To investigate the in vivo function of Elabela (ELA) in mammalian development.
  • To characterize the phenotypes of Ela null mice.
  • To elucidate the role of the ELA-APLNR axis in cardiometabolic health.

Main Methods:

  • Generation and analysis of Ela null mouse models.
  • Phenotypic characterization including embryogenesis and cardiovascular assessments.
Keywords:
APLNR signalingGPCRembryo developmentpreeclampsia

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  • Molecular and cellular analyses to understand ELA function.

    • Main Results:

    • Ela null mice exhibit severe developmental defects, including embryonic lethality.
    • Preeclampsia-like symptoms are observed in pregnant Ela null mice.
    • These findings underscore the critical role of ELA in mammalian embryogenesis and placental development.

    Conclusions:

    • Elabela (ELA) is indispensable for mammalian embryonic development and cardiovascular homeostasis.
    • The ELA-APLNR pathway is a critical regulator of pregnancy outcomes and cardiometabolic health.
    • Further research into ELA signaling may offer therapeutic targets for developmental disorders and preeclampsia.