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Do lipids shape the eukaryotic cell cycle?

Samuel Furse1, Gemma C Shearman2

  • 1NucReg Research Programme, Molekylærbiologisk institutt, Unversitetet i Bergen, Thormøhlens gate 55, 5008, Bergen, Norway; Core Metabolomics and Lipidomics Laboratory, Department of Biochemistry, University of Cambridge, c/o Level 4, Pathology Building, Addenbrookes Hospital, Cambridge, CB2 0QQ, United Kingdom..

Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
|October 2, 2017
PubMed
Summary
This summary is machine-generated.

Lipids undergo significant changes during the eukaryotic cell cycle, impacting cell structure and function. This review highlights the crucial roles of the lipidome in regulating cell cycle progression and its underlying mechanisms.

Keywords:
Cell cycleCell structureLipid abundanceLipid metabolismLyotropic phase behaviourMembranes

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • The cell cycle involves complex structural changes requiring cellular adaptation.
  • Recent studies reveal dynamic alterations in the eukaryotic lipidome throughout the cell cycle.
  • Lipids are increasingly recognized for their regulatory roles in fundamental biological processes.

Purpose of the Study:

  • To review current evidence on lipid profile modulations during the cell cycle.
  • To elucidate the mechanisms by which lipids control cell cycle progression.
  • To highlight the structural and functional importance of the lipidome in cell division.

Main Methods:

  • Synthesis of findings from biological, chemical, and physical studies.
  • Analysis of lipid composition changes across different cell cycle phases.
  • Examination of regulatory pathways involving lipids.

Main Results:

  • Lipidome alterations are integral to cell cycle progression in eukaryotes.
  • Specific lipid changes are associated with key structural transformations.
  • Lipids actively regulate protein activity, signaling, and membrane dynamics.

Conclusions:

  • Lipids are central regulators of cell cycle machinery.
  • Understanding lipid dynamics offers insights into cell cycle control.
  • Further research into lipid-mediated mechanisms is warranted.