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Related Concept Videos

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Related Experiment Video

Updated: Feb 22, 2026

Human Egg Maturity Assessment and Its Clinical Application
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Mild stimulation for in vitro fertilization.

Geeta Nargund1, Adrija Kumar Datta1, Bart C J M Fauser2

  • 1Create Fertility, London, United Kingdom.

Fertility and Sterility
|October 3, 2017
PubMed
Summary

Mild ovarian stimulation offers comparable pregnancy success to conventional IVF, with improved safety and patient tolerance. This approach enhances accessibility and reduces costs for fertility treatments.

Keywords:
Conventional stimulationin vitro fertilizationmild stimulationminimal stimulation

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Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF)

Background:

  • High-dose gonadotropins in IVF do not always improve outcomes.
  • Mild ovarian stimulation focuses on optimizing oocyte/embryo competence and endometrial receptivity.

Purpose of the Study:

  • To evaluate the efficacy and safety of mild ovarian stimulation protocols in IVF.
  • To compare mild IVF outcomes with conventional IVF treatments.

Main Methods:

  • Review of existing evidence on mild ovarian stimulation protocols.
  • Comparison of pregnancy rates, live birth rates, and cumulative pregnancy outcomes.
  • Assessment of safety profiles, including ovarian hyperstimulation syndrome and venous thromboembolism incidence.

Main Results:

  • Mild stimulation IVF shows comparable pregnancy and live birth rates to conventional IVF.
  • Cumulative pregnancy outcomes are similar despite fewer oocytes/embryos retrieved.
  • Mild IVF demonstrates a better safety profile and is more patient-friendly and cost-effective.

Conclusions:

  • Mild ovarian stimulation is an effective alternative to conventional IVF.
  • It offers significant advantages in safety, tolerability, and cost.
  • Widespread adoption could increase global accessibility of IVF treatments.