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Modified natural cycle in in vitro fertilization.

Jacqueline R Ho1, Richard J Paulson1

  • 1Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California.

Fertility and Sterility
|October 3, 2017
PubMed
Summary

Modified natural IVF cycles offer a cost-effective approach to fertility treatment. These cycles, which avoid extensive ovarian stimulation, provide acceptable pregnancy rates and are suitable for specific patient groups.

Keywords:
IVF stimulationIVMminimal stimulationmodified natural cycle IVFunstimulated IVF

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Early in vitro fertilization (IVF) relied on natural cycles but had low efficiency.
  • Ovarian stimulation was introduced to improve IVF success rates by increasing oocyte yield.
  • Technological advancements have led to a resurgence in natural and modified natural IVF cycles.

Purpose of the Study:

  • To describe the evolution and characteristics of modified natural IVF cycles.
  • To highlight the benefits and patient populations suitable for modified natural IVF.

Main Methods:

  • Modified natural IVF cycles involve ovulation triggering (e.g., with hCG) without prior gonadotropin stimulation.
  • GnRH antagonists are used to prevent premature ovulation while allowing follicle development.
  • Oocyte retrieval is scheduled precisely based on ovulation triggering.

Main Results:

  • Modified natural IVF cycles are associated with reduced medication costs.
  • These cycles achieve acceptable pregnancy rates.
  • They are particularly beneficial for patients at risk of ovarian hyperstimulation syndrome (OHSS), poor responders, and those aiming to prevent multiple births.

Conclusions:

  • Modified natural IVF cycles represent an evolution of IVF techniques, balancing efficiency with patient-specific needs.
  • These cycles offer a viable alternative to conventional stimulated IVF, especially for select patient demographics.
  • The approach optimizes resource utilization and minimizes risks associated with aggressive ovarian stimulation.