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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

13.1K

Systemic cryptococcosis in an immune-competent child

Arushi G Saini1, Sooraj Patil1, Triptee Agrawal1

  • 1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Journal of Infection and Public Health
|October 3, 2017
PubMed

Insights

This case report details disseminated cryptococcosis in an immunocompetent child. Early diagnosis and treatment of this rare fungal infection are crucial for patient survival.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatrics

Background:

  • Cryptococcus neoformans is an encapsulated yeast
  • It commonly affects immunocompromised individuals
  • Increasingly identified in immunocompetent hosts

Purpose of the Study:

  • To report a rare case of disseminated cryptococcosis
  • To highlight the presentation in a young, immunocompetent child
  • To emphasize the importance of early diagnosis and management

Main Methods:

  • Clinical presentation of a 4-year-old child with fever, abdominal pain, and skin lesions
  • Diagnostic workup including imaging, bone-marrow aspiration, and fine-needle-aspiration-cytology
  • Treatment with liposomal amphotericin-B, flucytosine, and fluconazole

Main Results:

  • Fine-needle-aspiration-cytology confirmed Cryptococcus in cervical lymph nodes
  • Serum latex-agglutination test showed a positive titer (1:256)
  • Disseminated infection involved reticuloendothelial and dermatological systems

Conclusions:

  • Disseminated cryptococcosis is rare in immunocompetent children
  • Timely diagnosis and management are critical for favorable outcomes
  • Infection requires prompt antifungal therapy to prevent severe complications

Keywords:
CryptococcusDisseminated cryptococcosisLymph nodeSkin infection

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